Revenge of the Birds on Jacoby Brissett

ArticleHow to Watch: Arizona Cardinals at San Francisco 49ers
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Jacoby Brissett #7 of the Arizona Cardinals calls a play at the line of scrimmage against the San Francisco 49ers during the first half at State Farm Stadium on November 16, 2025 in Glendale, Arizona.
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Brissett leads Cardinals as +8.5 underdog against 2-0 49ers in divisional matchup.

Jacoby Brissett is the Cardinals' starting QB facing the 49ers in a divisional matchup where Arizona is +8.5 underdog at Levi's Stadium. The Cardinals are 1-1 and the 49ers are 2-0; divisional performance is critical for Arizona's playoff positioning.

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